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Chronic pain managementSuboxone combines a synthetic opioid-like substance called buprenorphine with a drug called naloxone. Buprenorphine has two benefits. It activates the same receptor as opioids for analgesia, called the µ-receptor. Buprenorphine also blocks the receptor which causes dysphoria/euphoria, called the ĸ-receptor. In other words, it provides pain relief similar to opioids but without giving the patient the feeling of being “high”. Naloxone, on the other hand, helps deter abuse of the medication. If Suboxone is taken in a way it isn’t suppose to be taken (e.g. injected or insufflated), the naloxone with immediately inactivate the buprenorphine effectively “defeating the purpose” of abusing the drug.